SUPRAMOLECULAR MATRIX MATERIALS FOR PROSTATE CANCER CELL BIOLOGY


Year of Award:
2016
Award Type:
R21
Project Number:
1R21CA196434-01A1
RFA Number:
RFA-CA-15-004
Technology Track:
Biospecimen Science Technologies
PI/Project Leader:
VANDER GRIEND, DONALD JAMES
Other PI or Project Leader:
COLLIER, JOEL H
Institution:
UNIVERSITY OF CHICAGO
To develop a novel matrix for 3D cell culturing that offers significant advantages over existing gels like Matrigel for achieving more representative cultures and also offers built in capacities for monitoring specific biomarkers. The approach is based on synthesized proteins that self-assemble, and allow a variety of controls over the assembly and make-up of the gels.