Year of Award:
Molecular & Cellular Analysis Technologies
QUEIMADO, MARIA DE LURDES
Other PI or Project Leader:
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
To optimize and validate a recently developed quantitative DNA damage detection assay for high-throughput screening applications, and to compare it directly with existing techniques to show substantial improvements. Targeted improvements include superior sensitivity, specificity and ability to characterize a broader array of DNA adducts and other lesions than with currently available approaches.