Year of Award:
Molecular & Cellular Analysis Technologies
Other PI or Project Leader:
UNIVERSITY OF NEW MEXICO
To develop a novel bi-functional probe based on a design that would allow for inhibition of specific miRNA; a capability which has been difficult to achieve in a robust way with existing approaches. The proposed approach involves achieving much higher specificity by leveraging Dicer?s role in processing pre-miRNA into miRNA, and a proof-of-concept demonstration will be pursued on a number of well-known miRNA associated with cancer.