ADVANCED METHODS TO EVALUATE EXTRACELLULAR MATRIX AND CROSSLINKING IN THE TUMOR M


Year of Award:
2014
Award Type:
R33
Project Number:
CA183685
RFA Number:
RFA-CA-13-004
Technology Track:
Biospecimen Science Technologies
PI/Project Leader:
HANSEN, KIRK C
Other PI or Project Leader:
WEAVER, VALERIE MARIE
Institution:
UNIVERSITY OF COLORADO DENVER
The composition and architecture of the extracellular matrix (ECM) defines the metastatic outcome of tumor cells, specifically whether a tumor cell will transition from a non-invasive to an invasive phenotype. However, the extracellular biomolecules respo