PROTEIN PAINTING REVEALS HIDDEN PROTEIN-PROTEIN INTERACTION DOMAINS


Year of Award:
2013
Award Type:
R21
Project Number:
CA177535
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LIOTTA, LANCE ALLEN
Other PI or Project Leader:
N/A
Institution:
GEORGE MASON UNIVERSITY
We propose the creation of a wholly novel technology 'protein painting', for the rapid, direct isolation and sequencing of hidden native protein-proteininteraction domains. Protein-protein interactions are the basis of virtually all functional moleculr ev