A MULTIPLEX GENOME-WIDE SHRNA SCREENING PLATFORM FOR CANCER-LETHAL GENE DISCOVERY


Year of Award:
2009
Award Type:
R33
Project Number:
CA140039
RFA Number:
RFA-CA-08-008
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ELLEDGE, STEPHEN J
Other PI or Project Leader:
N/A
Institution:
BRIGHAM AND WOMEN'S HOSPITAL
A major bottleneck in devising effective targeted therapies for cancer treatment lies at the identification of relevant drug targets. Genetic screens that measure the outcome of inhibiting individual genes in cancer cells and in normal cells on a genome-s