EndoGenus Toolkit: A Biometric Method for Absolute Quantification of Tumor Markers by Massive Parallel Sequencing


Year of Award:
2018
Status:
Active
Award Type:
R21
Project Number:
CA229037
RFA Number:
RFA-CA-17-012
Technology Track:
Biospecimen Science Technologies
PI/Project Leader:
GULLEY, MARGARET L
Institution:
UNIV OF NORTH CAROLINA CHAPEL HILL
While massive parallel sequencing technology is quite mature, a problematic aspect is that plasma tumor markers are measured relative to total DNA, and total DNA levels vary with biologic factors like inflammation and with pre-analytic interferences such