Next-generation MOWChIP-seq for high-throughput epigenomic profiling using clinically relevant samples


Year of Award:
2017
Award Type:
R33
Project Number:
1R33CA214176-01
RFA Number:
RFA-CA-16-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LU, CHANG
Other PI or Project Leader:
N/A
Institution:
VIRGINIA POLYTECHNIC INST AND ST UNIV
Aberrant patterns in the epigenomic landscape have been closely associated with cancer.Deregulation of histone modifications silences tumor-suppressor genes, triggers geneticchanges via aberrant DNA repair/replication, and contributes to tumor heterogenei