TRANSLATIONAL MOLECULAR AND CELLULAR IMAGING TECHNOLOGIES FOR PROSTATE TUMOR PATHOLOGY


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA196458-01A1
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
BHARGAVA, ROHIT
Other PI or Project Leader:
CHEVILLE, JOHN C
Institution:
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
To validate a novel clinical diagnostic approach that combines the use of QD-based FISH for multiplexed molecular identification with IR imaging to provide histologic cell/tissue context for each marker measure, and do so using FFPE tissue. The proposal is that this would drastically improve diagnostic accuracy from existing techniques with an AUC of 0.9 with the proposed approach.