LARGE-SCALE INTEGRATION OF SINGLE CELL RNA-SEQ AND HIGH-CONTENT IMAGING FOR ANALYZING DRUG RESPONSE IN CANCER


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA202827-01
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SIMS, PETER ALAN
Other PI or Project Leader:
Not Applicable
Institution:
COLUMBIA UNIVERSITY HEALTH SCIENCES
To further develop and validate a recently developed microwell array system for single-cell analysis equipped with high-resolution optics and introducing optically-barcoded beads that will allow correlation of cellular metabolism, protein localization and translation, and cell cycling and signaling of intact cells with single-cell RNA-Seq.