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DEVELOPMENT OF PROTEASOME ADAPTORS TO CATALYTICALLY DEPLETE SPECIFIC PROTEINS FROM CELLS


Year of Award:
2016
Status:
Complete
Award Type:
R21
Project Number:
CA196456
RFA Number:
RFA-CA-15-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
MATOUSCHEK, ANDREAS
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF TEXAS, AUSTIN
To develop a novel strategy for depleting cancer-associated proteins from cells that exploits the proteasome-degradation mechanism in cells but side-steps ubiquitination. It is based on bifunctional molecules that will have both a proteasome binding domai