BRILLOUIN CONFOCAL MICROSCOPY FOR BIOMECHANICAL STUDIES OF METASTATIC CASCADE IN 3D MICROENVIRONMENTS


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA204582-01
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SCARCELLI, GIULIANO
Other PI or Project Leader:
Not Applicable
Institution:
UNIV OF MARYLAND, COLLEGE PARK
To further develop and validate a new microscopy technology, which allows for non-contact based assessment of sample elasticity in 3D. The technology has been demonstrated for non-cancer biological applications, but he is proposing to improve performance for cancer-relevant studies and will demonstrate this with a well-validated in vitro extravasation model.