ANALYSIS OF SCANT CANCER CELLS IN FINE NEEDLE ASPIRATES


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA202064-01
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WEISSLEDER, RALPH
Other PI or Project Leader:
Not Applicable
Institution:
MASSACHUSETTS GENERAL HOSPITAL
To optimize and validate a recently developed single-cell analysis platform which can simultaneously profile DNA, mRNA and proteins from cells isolated from fine needle aspirates. The validation work will be done with breast cancer patient samples in tandem with an evaluation of kinase inhibitor treatment to monitor response over time.