ADVANCED DEVELOPMENT AND VALIDATION OF 3 DIMENSIONAL SPHEROID CULTURE OF PRIMARY CANCER CELLS USING NANO3D TECHNOLOGY


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA206949-01
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SPICER, TIMOTHY PATRICK
Other PI or Project Leader:
Not Applicable
Institution:
SCRIPPS FLORIDA
To develop and validate a method for bioprinting 3D tumor spheroids, for use in high-throughput screening studies. These tools should contribute to drug repurposing and precision medicine initiatives. The technology involves the use of magnetic nanoparticles that decorate the surface of cells in suspension which facilitates manipulation of these into uniform spheroids that can be centered in each well to further facilitate automated screening of the spheroid arrays