MOLECULAR DETECTION OF DNA HYDROXYMETHYLATION FOR CANCER SCREENING


Year of Award:
2015
Award Type:
R21
Project Number:
CA193067
RFA Number:
RFA-CA-14-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HALL, ADAM ROGER
Other PI or Project Leader:
N/A
Institution:
WAKE FOREST UNIVERSITY HEALTH SCIENCES
This project will develop a strategy to detect levels of hydroxymethylation (hmC) in genomic DNA. We will first combine a method to selectively attach a biotin to hmC with our demonstrated technique of detecting single biotin modifications in DNA to demon