CELL-SPECIFIC ISOTOPE LABELING TO TRACK INTERCELLULAR METABOLITE EXCHANGE IN CANCER


Year of Award:
2015
Award Type:
R21
Project Number:
CA191097
RFA Number:
RFA-CA-14-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
PATTI, GARY JOSEPH
Other PI or Project Leader:
N/A
Institution:
WASHINGTON UNIVERSITY
We propose to develop a cell-specific isotope labeling technology to study cancer metabolism and metabolite exchange in the intact animal. Our technology addresses a major limitation of most metabolomic studies on cancer, namely that they have been mostly