VALIDATING TECHNOLOGY TO OPTIMIZE ANTIBODY AFFINITY FOR TARGETING THERAPEUTICS


Year of Award:
2014
Award Type:
R33
Project Number:
CA177333
RFA Number:
RFA-CA-13-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
FEDERSPIEL, MARK J
Other PI or Project Leader:
N/A
Institution:
MAYO CLINIC ROCHESTER
Antibody-based therapeutics have now had success in the clinic for the treatment and diagnosis of a variety of cancers. The affinity and specificityof the antibody for the target ligand determines the specificity of therapeutic delivery and off-targe side