IN VIVO METAL-FREE CYCLOADDITION CHEMISTRY DRIVEN PRETARGETED CANCER RADIOTHERAPY


Year of Award:
2013
Award Type:
R21
Project Number:
CA177526
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
QUINN, THOMAS P.
Other PI or Project Leader:
ROBILLARD, MARC
Institution:
UNIVERSITY OF MISSOURI-COLUMBIA
The goal of the proposed research is to develop novel metal-free 'click chemistry' pretargeted approaches for cancer radioimmunotherapy (RIT). It is hypothesized that novel in vivo cycloaddition chemistry will greatly facilitate the use of pretargeted ant