IN VIVO DETECTION AND GENOME-WIDE LOCATION ANALYSIS OF DNA-ADDUCTS


Year of Award:
2013
Award Type:
R21
Project Number:
CA177519
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HARISMENDY, OLIVIER
Other PI or Project Leader:
HOWELL, STEPHEN B
Institution:
UNIVERSITY OF CALIFORNIA SAN DIEGO
DNA adducts are the hallmark and most common form of DNA damage in the cell. They result from environmental carcinogen exposure (such as UV) or during chemotherapy using DNA modifying agents like cisplatin (cDDP) or alkylators such as chlorambucil (CLB).