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OPTIMIZATION OF MULTIVALENT LIGANDS BY SUPER-RESOLUTION MICROSCOPY TO TREAT CANCE


Year of Award:
2013
Status:
Complete
Award Type:
R21
Project Number:
CA174608
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WILLIAMS, JOHN CHARLES
Other PI or Project Leader:
TALISMAN, TIJANA
Institution:
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
Monoclonal antibodies (mAbs) represent an important and rapidly growing class of therapeutics to treat cancer and other diseases, and their success has lead to extensive re-engineering efforts to improve and extend their functionality. Recently, we have u