KINASE BINDING FLUORESCENT PROBES FOR ASSAYING CELLULAR RECEPTOR POPULATIONS


Year of Award:
2013
Award Type:
R21
Project Number:
CA182341
RFA Number:
RFA-CA-13-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WILSON, JAMES NORBERT
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MIAMI CORAL GABLES
Receptor tyrosine kinases are primary targets for small molecule and monoclonal antibody chemotherapies given their key role in intracellular signaling pathways, regulation of cell growth and cell survival. Immunohistochemical (IHC) analysis of receptor l