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DEVELOPMENT OF MASSSQUIRM TO QUANTITATIVELY MEASURE LYSINE METHYLATION


Year of Award:
2013
Status:
Complete
Award Type:
R33
Project Number:
CA173264
RFA Number:
RFA-CA-12-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
TACKETT, ALAN JACKSON
Other PI or Project Leader:
N/A
Institution:
UNIV OF ARKANSAS FOR MED SCIS
The methylation of histone lysine residues has been correlated to numerous phenotypes of cancer. Histone lysine residues can have up to three methyls added and each state can have clearly different cellular roles. For years, researchers in epigenetics (in