EXOSOMAL RECOMBINASE-A TOOL TO DISSECT METASTASIS AND THE CANCER MICROENVIRONMENT


Year of Award:
2012
Award Type:
R21
Project Number:
CA173164
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
STEINMAN, RICHARD A
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
We propose a tool to engineer cancer or host cells to irreversibly mark nearby cells by means of novel 'exosomal Cre recombinase' constructs. By creating cancer cells that transport Cre, the proximal microenvironment in Cre-responsive animals can be analy