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DEVELOPING NOVEL TECHNOLOGY FOR MAPPING DYNAMIC ONCOPROTEIN INTERACTION NETWORKS


Year of Award:
2012
Status:
Complete
Award Type:
R21
Project Number:
CA160060
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
WANG, ZHENGHE
Other PI or Project Leader:
N/A
Institution:
CASE WESTERN RESERVE UNIVERSITY
Many oncoproteins and tumor suppressive proteins shuttle between the cytosol and nucleus and thus interact with changing sets of protein partners in different sub-cellular compartments. Furthermore, increasing evidence indicates that oncogenic mutations o