CONTROLLED PREMATURE TERMINATION OF TRANSLATION TO GENERATE DESIGNATED TRUNCATED


Year of Award:
2012
Award Type:
R21
Project Number:
CA173303
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
CARTEGNI, LUCA
Other PI or Project Leader:
N/A
Institution:
SLOAN-KETTERING INST CAN RESEARCH
Many diseases, including several forms of cancer, depend on the inappropriate expression of pathological proteins, such as oncogenes. Frequently, the structure-function of these proteins belies a modular construction, with an essential functional domain i