IDENTIFICATION OF SOMATIC MUTATIONS IN RARE SUBCLONES OF SOLID TUMORS


Year of Award:
2011
Award Type:
R21
Project Number:
CA155615
RFA Number:
RFA-CA-10-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HARISMENDY, OLIVIER
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CALIFORNIA SAN DIEGO
Cells within a tumor sample are known to be heterogeneous, due to the contamination from non-malignant tissue or the presence of multiple sub-clones, each carrying different somatic mutations. The majority of somatic mutations identified to date are clust