TECHNOLOGY FOR DETECTION AND QUANTITATION OF TELOMERIC DNA ABERRATIONS IN CANCER


Year of Award:
2010
Award Type:
R21
Project Number:
CA143349
RFA Number:
RFA-CA-09-008
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
RIETHMAN, HAROLD
Other PI or Project Leader:
N/A
Institution:
WISTAR INSTITUTE
Telomeric DNA abnormalities are a critical and universal aspect of carcinogenesis. The gradual replicative loss of telomeres ultimately results in telomere dysfunction and plays a role in many age-related diseases, including cancer. Sporadic telomere dele