FRET-BASED BIOSENSORS TO MONITOR REDOX IN CELL CYCLE REGULATION


Year of Award:
2010
Award Type:
R33
Project Number:
CA137719
RFA Number:
RFA-CA-09-007
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
KENIS, PAUL J. A.
Other PI or Project Leader:
GASKINS, H. REX
Institution:
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
Cancer can be viewed as a state in which the balance between cell proliferation and cell death aberrantly favors the former. We and others have discovered that the intracellular redox environment exerts a profound influence on the normal cellular processe