MICROFLUIDIC 3D SCAFFOLD ASSAY FOR CANCER CELL MIGRATION AND INTRAVASATION


Year of Award:
2009
Award Type:
R21
Project Number:
CA140096
RFA Number:
RFA-CA-08-006
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
CHAREST, JOSEPH LEO
Other PI or Project Leader:
N/A
Institution:
CHARLES STARK DRAPER LABORATORY
Migration through extra-cellular matrix (ECM) and intravasation across a cellular barrier comprise the initial, rate-limiting steps of cancer metastasis. Physiologically relevant and well-controlled models that mimic the in vivo tumor microenvironment wil