A CHEMICAL CROSSLINKING STRATEGY TO DETERMINE DNA METHYLATING PROTEIN COMPLEXES


Year of Award:
2009
Award Type:
R21
Project Number:
CA138310
RFA Number:
RFA-CA-08-007
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
GODLEY, LUCY ANN
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CHICAGO
Epigenetic changes alter chromatin structure, thereby regulating gene transcription. In normal cells, repetitive DNA is hypermethylated and transcriptionally silent, whereas transcribed gene promoters are undermethylated and associated with open chromatin