rePPI-i: A system for the rapid continuous evolution of protein-protein interaction inhibitors


Year of Award:
2017
Award Type:
R21
Project Number:
1R21CA217754-01
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
DICKINSON, BRYAN
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CHICAGO
The long-term goal of this project is to develop a rapid, cost-effective, efficacious evolutionplatform for the creation of selective inhibitors of target protein-protein interactions (PPIs). Theemergence of cancer systems biology approaches has revealed