A novel time-resolved fluorescence-based high-throughput screening technology for discovering allosteric kinase inhibitors


Year of Award:
2017
Award Type:
R21
Project Number:
1R21CA217695-01
RFA Number:
RFA-CA-16-001
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LEVINSON, NICHOLAS MARK
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF MINNESOTA
Allosteric kinase inhibitors are highly sought after as cancer drugs to override resistance to conventional kinaseinhibitors, a major clinical problem that severely limits the duration of response to many front-line cancertherapies. Unfortunately, most ex