CHARGE SENSITIVE OPTICAL DETECTION FOR HIGH-THROUGHPUT STUDY OF SMALL MOLECULES


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA202834-01A1
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
TAO, NONGJIAN
Other PI or Project Leader:
Not Applicable
Institution:
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
To further develop and validate a biosensor technology that was previously supported with an IMAT R21. These so-called charge-sensitive optical detection probes offer unprecedented capability for measuring small molecule binding kinetics, and further development in this case involves incorporating these sensors into microwell plates and validation for use in high-throughput drug screening applications in several head-to-head comparisons.