HIGH THROUGHPUT GO CHIP ISOLATION OF LUNG CTCS FOR MOLECULAR DIAGNOSIS AND DRUG TESTING


Year of Award:
2016
Award Type:
R33
Project Number:
1R33CA202867-01
RFA Number:
RFA-CA-15-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
NAGRATH, SUNITHA
Other PI or Project Leader:
RAMNATH, NITHYA
Institution:
UNIVERSITY OF MICHIGAN
To optimize and validate their novel liquid biopsy processing platform (the “GO Chip”) for isolating tumor cells from blood samples followed by expansion and genomic analysis of the captured cells, and allow for screening of different drugs on the same platform. Key advantages of the proposed platform is the clever design enabling processing of 10mL of whole blood in one hour, with in situ 3D co-culture and subsequent targeted analysis or drug testing all on the same chip.