CRISPR-BASED EPIGENETIC MODIFIERS


Year of Award:
2016
Award Type:
R21
Project Number:
1R21CA204563-01
RFA Number:
RFA-CA-15-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SEGAL, DAVID J
Other PI or Project Leader:
Not Applicable
Institution:
UNIVERSITY OF CALIFORNIA AT DAVIS
To modify the dCas9 enzyme of the CRISPR system to create a better tool for site specific editing of epigenetic marks. This innovative design involves a unique combination of functional elements yielding a system addressing a variety of shortcomings with regards to existing epigenetic editing approaches.