DEVELOPMENT OF NOVEL CHEMICAL PROBES TO MAP S-NITROSYLATION IN CANCER


Year of Award:
2016
Award Type:
R21
Project Number:
1R21CA202852-01
RFA Number:
RFA-CA-15-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HELD, JASON M.
Other PI or Project Leader:
BIRMAN, VLADIMIR B
Institution:
WASHINGTON UNIVERSITY
To develop a novel probe for S-nitrosothiols in living cells in tissue which would create, for the first time, a tool capable of trapping these reversible covalent binders and allow direct study of the role they play in cell signaling.