HIGH-THROUGHPUT ON-CHIP PLATFORM FOR INTERROGATION OF MITOCHONDRIAL MEMBRANE POTENTIAL AND APOPTOSIS


Year of Award:
2015
Award Type:
R33
Project Number:
CA182384
RFA Number:
RFA-CA-14-004
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
BURKE, PETER J.
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CALIFORNIA-IRVINE
In the proposed studies, we aim to develop and validate technology to allow for high-throughput assays of inhibitors and inducers of mitochondrial depolarization, the point of no return for apoptosis. As apoptosis is a key unregulated pathway in tumor pro