AN OPTIMIZED DESIGN FOR SINGLE COPY SHORT HAIRPIN RNAI


Year of Award:
2015
Award Type:
R21
Project Number:
CA196379
RFA Number:
RFA-CA-14-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
HAMMOND, SCOTT M
Other PI or Project Leader:
N/A
Institution:
UNIV OF NORTH CAROLINA CHAPEL HILL
Short hairpin RNA (shRNA) mediated RNAi is a well-established method for investigating cancer pathways and is a promising future therapeutic strategy. In particular, delivery of shRNAs by retroviral transduction enables RNAi knockdown in mouse models and