NANOSCALE TOOLS FOR FUNCTIONAL STUDIES OF CANCER-RELEVANT CHROMATIN MODIFICATIONS


Year of Award:
2013
Award Type:
R21
Project Number:
CA174583
RFA Number:
RFA-CA-12-002
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
CASTRO, CARLOS E.
Other PI or Project Leader:
N/A
Institution:
OHIO STATE UNIVERSITY
Dynamic organization of the human genome into chromatin regulates transcription initiation and elongation. Defects in chromatin modifications, assembly, disassembly and remodeling result in misregulation of oncogenes, which are associated with numerous ca