MOLECULAR EVOLUTION OF MULTIFUNCTIONAL DNA NANOPARTICLES


Year of Award:
2011
Award Type:
R21
Project Number:
CA143362
RFA Number:
RFA-CA-10-005
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
MESSMER, BRADLEY T
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF CALIFORNIA SAN DIEGO
We have developed a DNA nanoparticle library technology for the selection of cell binding DNA nanoparticles. Rolling circle amplification (RCA) of circular oligonucleotide templates containing randomized nucleotides produces libraries of single stranded D