SCANNING CORRELATION MICROSCOPY METHODS FOR QUANTIFYING DNA REPAIR KINETICS


Year of Award:
2011
Award Type:
R21
Project Number:
CA154958
RFA Number:
RFA-CA-10-003
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
ALEXANDRAKIS, GEORGIOS
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF TEXAS ARLINGTON
The kinetics of most fluorescently tagged DNA repair proteins subsequent to exposure to ionizing radiation, or radiomimetic chemical agents, cannot be quantified in the living cell without serious perturbation of the system under study. With the exception