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Predicting Tumor Heterogeneity Evolution After Therapy In Patient-Derived Ex Vivo Glioblastoma Organoids


Year of Award:
2018
Status:
Complete
Award Type:
R21
Project Number:
CA229027
RFA Number:
RFA-CA-17-012
Technology Track:
Biospecimen Science Technologies
PI/Project Leader:
SKARDAL, ALEKSANDER (contact); STROWD, ROY ERVIN
Institution:
WAKE FOREST UNIVERSITY HEALTH SCIENCES

PROJECT SUMMARY Glioblastoma (GBM) is a lethal, incurable form of cancer in the brain. Even with maximally aggressive surgery and chemoradiotherapy, median survival is 14.5 months. These tumors infiltrate normal brain tissue, are surgically incurable, and