Optogenetic tools for the dissection of oncogenic signaling mediated by kinases


Year of Award:
2018
Award Type:
R21
Project Number:
1R21CA223915-01
RFA Number:
RFA-CA-17-010
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
KARGINOV, ANDREI V
Other PI or Project Leader:
REHMAN, JALEES
Institution:
UNIVERSITY OF ILLINOIS AT CHICAGO
Aberrant signaling by protein kinases is one of the driving forces of tumorigenesis. Transition fromphysiological to oncogenic processes is often triggered by changes in temporal and spatial regulation ofkinases. Dissection of these events is limited by t