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Novel NeuCode Tagging Reagents for Identification and Quantification of Intact Proteoforms in Cancer Tissues


Year of Award:
2018
Status:
NCE
Award Type:
R21
Project Number:
CA223887
RFA Number:
RFA-CA-17-010
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SMITH, LLOYD M
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF WISCONSIN-MADISON

In this proposal we address a very substantial limitation in the ability of existing technologies toprovide critical proteomic information from normal and cancer tissues. In standard proteomicanalyses, proteins in complex protein mixtures such as total ce