An integrated therapeutic T cell receptor screening platform for adoptive cell therapy in cancer


Year of Award:
2018
Award Type:
R33
Project Number:
1R33CA225539-01
RFA Number:
RFA-CA-17-011
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
JIANG, NING
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF TEXAS, AUSTIN
Recent successes of T cell receptor based adoptive cell transfer therapy have generated new excitement aboutthis therapeutic approach. However, lacking a high-throughput method of screening of naturally occurring high-affinity therapeutic T cell receptors