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High-throughput super-resolution imaging of chromatin structures at different epigenetic states


Year of Award:
2018
Status:
NCE
Award Type:
R33
Project Number:
CA225494
RFA Number:
RFA-CA-17-011
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LIU, YANG
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF PITTSBURGH AT PITTSBURGH

The perturbation in chromatin structure is one of the most striking and characteristic changes in cancer cellsand remains one of the hallmarks in cancer diagnosis. At the molecular level, it is well recognized that aberrantepigenetic marks of DNA methylat