Error message

  • Deprecated function: Optional parameter $feed_nid declared before required parameter $context is implicitly treated as a required parameter in include_once() (line 1439 of /local/drupal/imat/includes/bootstrap.inc).
  • Deprecated function: Optional parameter $input declared before required parameter $form_state is implicitly treated as a required parameter in require_once() (line 12 of /local/drupal/imat/sites/all/modules/media/media.module).
×

Discovering hybrid inhibitors for tumor microenvironment disruption


Year of Award:
2018
Status:
NCE
Award Type:
R21
Project Number:
CA214239
RFA Number:
RFA-CA-17-010
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
VAN DEVENTER, JAMES ALLEN
Institution:
TUFTS UNIVERSITY MEDFORD

Although cancer-promoting activities of extracellular proteases and peptidases in the tumor microenvironment are well known, the specific disruption of a single enzyme in basic and translational settings remains a fundamental challenge. For example, the u