Discovering hybrid inhibitors for tumor microenvironment disruption


Year of Award:
2018
Status:
Active
Award Type:
R21
Project Number:
CA214239
RFA Number:
RFA-CA-17-010
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
VAN DEVENTER, JAMES ALLEN
Institution:
TUFTS UNIVERSITY MEDFORD
Although cancer-promoting activities of extracellular proteases and peptidases in the tumor microenvironment are well known, the specific disruption of a single enzyme in basic and translational settings remains a fundamental challenge. For example, the u