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CRISPR-based Enhanced Molecular Chipper Technology for Identifying Functional Noncoding Elements in Cancer


Year of Award:
2018
Status:
NCE
Award Type:
R33
Project Number:
CA225863
RFA Number:
RFA-CA-17-011
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
LU, JUN
Other PI or Project Leader:
N/A
Institution:
YALE UNIVERSITY

More than 98% of the human genome is composed of non-coding sequences. Noncodinggenomic elements, such as regulatory elements for gene expression and noncoding RNAs, areincreasingly being recognized to play critical roles in cancer biology. However, large