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Autohistomagnetic Isolation of Tumor-reactive T-cells


Year of Award:
2018
Status:
Complete
Award Type:
R21
Project Number:
CA214285
RFA Number:
RFA-CA-17-010
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
MAILLOUX, ADAM WILLIAM
Institution:
H. LEE MOFFITT CANCER CTR & RES INST

Adoptive cell therapy of autologous tumor-infiltrating lymphocytes (TIL) can now mediate objective cancer regression in 50% of patients with metastatic melanoma. While TIL therapy has made incremental improvements over recent decades, the fundamental meth