Advanced development and validation of genome-scale molecular diagnostics for microsatelliteinstability using targeted molecular counting methods


Year of Award:
2018
Award Type:
R33
Project Number:
1R33CA222344-01
RFA Number:
RFA-CA-17-011
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SALIPANTE, STEPHEN J
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF WASHINGTON
Microsatellite Instability (MSI), the spontaneous loss or gain of nucleotides from repetitive DNA tracts, is amolecular phenotype in oncology that is associated with genomic hypermutability and mutations in DNA repairenzymes. Although originally described