Error message

  • Deprecated function: Optional parameter $feed_nid declared before required parameter $context is implicitly treated as a required parameter in include_once() (line 1439 of /local/drupal/imat/includes/bootstrap.inc).
  • Deprecated function: Optional parameter $input declared before required parameter $form_state is implicitly treated as a required parameter in require_once() (line 12 of /local/drupal/imat/sites/all/modules/media/media.module).
×

Advanced development and validation of genome-scale molecular diagnostics for microsatelliteinstability using targeted molecular counting methods


Year of Award:
2018
Status:
NCE
Award Type:
R33
Project Number:
CA222344
RFA Number:
RFA-CA-17-011
Technology Track:
Molecular & Cellular Analysis Technologies
PI/Project Leader:
SALIPANTE, STEPHEN J
Other PI or Project Leader:
N/A
Institution:
UNIVERSITY OF WASHINGTON

Microsatellite Instability (MSI), the spontaneous loss or gain of nucleotides from repetitive DNA tracts, is amolecular phenotype in oncology that is associated with genomic hypermutability and mutations in DNA repairenzymes. Although originally described